Dephest 

The most in-depth type of said subject.

"The dephest of conversations occur here."

Dephest by retxad May 11, 2019

Depresturbation

The act of occupying oneself during an otherwise overwhelming stressful or depressing situation (hence the name) using manual stimulation onto one's sexual endowments; in a simple sense, depressed masturbation.

Dude did you see Michael after his father's death?
Ah yeah, he's executing the depresturbation technique.

Depresturbation by Matres May 7, 2013

deprestapated 

When depression causes constipation.

I'm so deprestapated, my boyfriend broke up with me and I haven't pooed in 3 days.

deprestapated by singinjobanana June 19, 2009

deprestlayer 

Cool person slang

Yo deprestlayer what’s poppin

deprestlayer by Deprestlayer October 8, 2020

deprestidigitation

Depression, when the magic goes out of digital life.

She had been enthralled with Facetime, Zoom, texts and emails, yet now was overwhelmed with deprestidigitation, yearning for a touch, a smile, eye-contact, the unfiltered sound of a loving voice.

deprestidigitation by Monkey's Dad April 2, 2020

crippling depreston 

When your name is Preston and you can't escape the puns of your name so it actually puts you in a state of depression

Wow Preston! You seem sad. Do you have "Crippling Depreston?"

crippling depreston by Cereal Guy November 16, 2016

Deprestion 

An illness that develops from losing too many games at competitive shooters. One suffering from this illness may present certain symptoms like Arthritis and hallucinations featuring ducks in your peripheral vision.

Jonathan has Deprestion

Deprestion by DuckyBoy123 June 6, 2018