Cackle Spackle Share definition Flag The debris propelled from one's mouth upon bursting into laughter. Don't make someone laugh after they eat a handful of peanuts, otherwise you will feel the force of their cackle spackle. Cackle Spackle by Da Moustafocka January 9, 2010 0 0 Get merch Get the Cackle Spackle mug. Buy Now — $32.95 See more merch