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Cobra Oprah 

cobra= lashing out poisonous mammal, ambushful and unpredictable.

oprah= powerful female.

cobra + oprah = a powerful poisonous female mammal that lashes out on contact.

synonymous with "bitch" , "crazy woman", or " your mother in law"
As in

"boy don't make me go cobra oprah on yo ass!!!"

"ooooooo babyyy, that girl got some cobra oprah in her step, mmmmmmhmmm make a grown man cry"

"I left that bitch tomorrow she too cobra oprah fo me, ya on level?"
Cobra Oprah by couturegirl08 April 12, 2010

Looks like Oprah 

Something you say when you have absolutely no idea what that subject of discussion is/am/are/should be.
justin: yeah dude it's so like...
abadi: so what?
justin: you know it's like...
abadi: ohhh... It looks like oprah
justin: YEAH!
Looks like Oprah by Constante Firme February 27, 2005

Metropolitan Oprah House 

A fancy-schamncy concert-hall in NYC that features everyone's favorite cloyingly-sweet TV personality.
Other folks can attend the fancy hyped programs at the Metropolitan Oprah House if they choose, but I am not really into all the glitz and drama --- gimme a nice quiet friendly backyard barbecue or simple country-folk musical-shindig EVERY time.

Reverse Oprah 

One female receiving gifts from multiple males at the same time; gifts being loads of cum
Hey John, mike, and Keith, let’s go give that bitch the Reverse Oprah
Reverse Oprah by Mikehawkins May 13, 2021

The Oprah Conjecture 

The Oprah Conjecture is the theory that any organized conspiracy of substantial is impossible because one of the members would reveal the secret to Oprah Winfrey, who would publicize it on her show.
The queen cannot be an alien, for if she was The Oprah Conjecture, tells us it would have already been revealed.

Cloning Oprah 

One of many examples that can be used to describe taking a shit.
I spent an hour in the bathroom the morning. I was busy Cloning Oprah.