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Holy Ryan Seacrest 

Commonly utilized as an expression denoting moderate excitement, amusement, and/or mild indifference when cussy words are simply unacceptable, i.e. You're in a church/at a daycare/in a Carl's Junior drive-thru ordering a Hot Carl. When Holy AIDS has too much zazz and personality, and when Holy Shit just isn't feasible or polite, unzip your grab bag of phrases and reach for the stars. And, banality.
#1: "Did you see last night's episode of____? Holy Ryan Seacrest! It was so flamboyantly average, I could actually feel myself dying a little bit inside with every passing minute that I continued watching. Naturally, I recorded it so I could review it and subsequently spark uninspired discussions on my Facebook page, both for, and against, topics of my choosing surrounding said show."

#2: "I ordered a Big Mac and found myself having to take a--Holy Ryan Seacrest, did you just see that mime across the street get beat up by those ventriloquists?"

#3: "I just flew here from Cleveland and Holy Ryan Seacrest are my arms tired."

#4: "Your command of the English language has been classified as mildly-illiterate at best and you can barely secure the velcro on your dress shoes, yet you were voted in as Leader of the Free World for eight years? Holy Ryan Seacrest- I didn't think you had it in you, Georgie. Kudos."
Holy Ryan Seacrest by amateurmetheus September 26, 2009
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Holy Trinity 

The distinctly unholy act of involuntarily vomiting, pissing and shitting yourself due to excessive drinking. All three must usually be within a small radius of each other for this to count as doing a holy trinity.
Phil was so drunk that night, he just had no idea what was going on... he even did a holy trinity on the statue outside - brutal.
Holy Trinity by camlaxer March 8, 2010

Holy Child

Holy Child girls sweat Holy Cross girls. They just changed CROSS to CHILD so they can think like they're cooler. They're all ugly and wish they could get as many guys as the holy cross girls.
Prep Boy: My girlfriend goes to Holy Child
Gonzaga boy: DAMN HOLY CROSS!!
Prep Boy: No holy child.
Gonzaga boy: where the fuck is that?
Holy Child by anonymous December 19, 2004

holy cow 

A cow blessed by a high priest
I bless this cow...(as a priest dips him in holy water)
holy cow by Jim Beam May 31, 2004

Holy Bible 

See "Bull Shit"
Wanna look at a good joke book? read the Holy Bible
Holy Bible by Ray the Atheist November 2, 2011
When the number π self-proclaims to be God’s “anointed” number, because it is the most famous constant in the whole of mathematics—no number has had such an impact on popular culture that even some mathophobic folks wouldn’t mind tattooing it conspicuously to look mathematically cool in the same way that unbelievers wear a cross to appear religious.
Because π is the beloved symbol of choice for millions of people worldwide, or even deified by some pi fanatics and numerologists, it’s not preposterous for the “sacred number” to be conferred the title of “Holy Pi.”
Holy Pi by MathPlus May 28, 2021

Holy Grail 

The voyeuristic view received as a result of a woman inadvertently or carelessly exposing her genitals when not wearing panties or "rocking it commando" while wearing a skirt or a pair of shorts.
Joey: "Did you see that shit? She's rocking it commando."

Sid: "That's the holy grail right there, son!! It's a little blown out though."
Holy Grail by Chaos Spawn March 17, 2010