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Yo chromosomes got extra homes 

The most devastating of any yo or ur insults, possibly deadly
Tommy: hey Leo, Yo mum gay
Leo:Yo chromosomes got extra homes
Tommy:*ceases to exist*

Yo momma's so fat that even Dora will have trouble exploring her 

Slang. Yo mama weighs so much Dora can’t navigate around her. Dora explores anything!
How much does your mom weigh? Um 300 pounds. Shit! Yo momma's so fat that even Dora will have trouble exploring her! Dora can’t navigate around her. Dora explores anything!