You Don't Only Live Once. A play on Drake's unoriginal motto "YOLO" that people are saying to make themselves feel up to date with the newest unoriginality that makes up today's pop culture.
Drake: "I'm a loser from Degrassi that at some point felt I had talent to offer! YOLO!
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.