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This stands for 'shut the fuck up you fucking piece of shit'.
Most people use this word when they are angry or annoyed.
Girl: Omg, Stacy is having an awesome party tomorrow!!!! You have to come!!! There are going to be a lot of really cute guys there and a lot of food and we are all going to play spin the bottle and get locked up in a closet with the other person for 10 minutes!!!! Omg..... <Other girl interrupts her>
Girl #2: OMFG!!!!! JUST STFUYFPOS!!!!!! DAMN! YOU ARE SOOOOOO FUCKING ANNOYING!
stfuyfpos by MAMA123 June 5, 2010
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STFUYCSPOS 

shut the fuck up you cock sucking piece of shit
person a: a/s/l?

person b: STFUYCSPOS!
STFUYCSPOS by Chino_PD December 2, 2003

STFUYPOS 

Shut the fuck up you piece of shit.
Carol: I think we had enough to drink
Tristian: STFUYPOS
STFUYPOS by my.liege October 16, 2020

STFUSPOS 

Simply: Shut The Fuck Up Stupid Peice Of Shit

This is often used to exspell anger at something annoying or loud.
Car: "*Break Clang Screet*"

Bill: STFUSPOS
STFUSPOS by Turco July 2, 2008

stfuyfbcs 

"shut the fuck up you stupid bitch cock sucker" when you want to use most of the 7 "bad" words in one sentence
stfuyfbcs
stfuyfbcs by joeycrack July 10, 2007

stfuyuposihydyff 

Shut the fuck up you ugly pice of shit I hope you die you fat fuck
Him: Hey

Her: stfuyuposihydyff I know what yo did

stfuyuposihydyff 

Shut the fuck up you ugly pice of shit I hope you die you fat fuck
Him: Hey

Her: stfuyuposihydyff I know what yo did