I sister/friend that is hot like a burn/blister on the inside and on the outside
Nah bruh, I can’t date her.. she’s my sister blister!
by snilocnahte October 24, 2017
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A nun with a prominent and questionable cold sore.
Father Mulveaney couldn't help but notice the blistered sister sitting in the front row at mass. He made an appointment with his family doctor after service just to be safe.
by Eaton Holgoode October 9, 2015
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1. Referring to a female that is known to have a sexually transmitted (venereal) disease.
Dude, I'm going to ask Dolores out next Saturday.

Don't do it man! She is the Sister with a blister!

Man, she is so HOT! Can't belive she is the sister with a blister.
by nczn February 15, 2010
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Someone who shows up when the real work is done then acts like they took part.
Dilbert and the intern spent days proofing the manual then Wally pulled a blister sister and ran a final spell check to claim all the work.
by billmanak February 10, 2009
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