Definitions by nczn

Sister with a blister 

1. Referring to a female that is known to have a sexually transmitted (venereal) disease.

Dude, I'm going to ask Dolores out next Saturday.

Don't do it man! She is the Sister with a blister!

Man, she is so HOT! Can't belive she is the sister with a blister.

Sister with a blister by nczn February 15, 2010