1. Referring to a female that is known to have a sexually transmitted (venereal) disease.
Dude, I'm going to ask Dolores out next Saturday.

Don't do it man! She is the Sister with a blister!

Man, she is so HOT! Can't belive she is the sister with a blister.
by nczn February 15, 2010
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I sister/friend that is hot like a burn/blister on the inside and on the outside
Nah bruh, I can’t date her.. she’s my sister blister!
by snilocnahte October 24, 2017
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