As coined in the book Diary of a Wimpy Kid: Rodrick Rules, middle son Greg Heffley uses this word to call his younger brother, Manny, as an insult without getting punnished for saying a bad word. Ploopie can be used when small children are about, intead of swearing you can use ploopie to replace vulgar sayings.
At church when you drop a Bible, "Son of a Ploopie, I dropped the Bible!"
In public when your friends do something stupid "You Ploopie, you need to knock it off!"
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).
Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.
After school, The Modells on Jamaica Ave was active. Respectfully.