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As coined in the book Diary of a Wimpy Kid: Rodrick Rules, middle son Greg Heffley uses this word to call his younger brother, Manny, as an insult without getting punnished for saying a bad word. Ploopie can be used when small children are about, intead of swearing you can use ploopie to replace vulgar sayings.
At church when you drop a Bible, "Son of a Ploopie, I dropped the Bible!"
In public when your friends do something stupid "You Ploopie, you need to knock it off!"
Ploopie by Lulu Pepperchini June 30, 2011
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A monster that hides in your sheets and drags you under while you are sleeping
The ploopie dragged the little girl underneath her sheets
ploopie by hfioahdga April 15, 2020
Related Words

Making Poopies 

Making poopies refers to the act of taking a dump or taking a shit. This is the process of emitting fecal matter out of one's posterior orifice. I don't know why the term: 'taking a shit' caught on, since you're actually 'leaving' a shit'. Making poopies can be a means of describing your current situation or that of someone or something else. This expression can be used in differing tense's as given in the examples below.
Honey, you're not gonna believe this, but I have to make poopies.

Hey Louie, where's the poker dealer? Oh, he's in the shitter out back making poopies

Hey everybody, I just made poopies in my pants!
Making Poopies by Big Ed Moustapha October 26, 2009

Loose Poopie

Synonymous with diareara. Simply another word to use while being expressive, but not redundant. Plural: Loose Poopies
I've gotta stop eating those damn peppers before I bonk my babe. Tried to slip out a silent one during the hot action and out came some loose poopies. She was pissed but laughed anyway. Made me sleep on the couch.
Loose Poopie by Big Ed Moustapha September 26, 2008

Loud Poopie 

Synonymous with FART. Simply another word to use while being expressive, but not redundant.
Hey, I just cut a loud poopie. It rattled the windows. At least a 5 on the Richter scale.
Loud Poopie by Big Ed Moustapha September 26, 2008

Poopie Paralyzer 

When one cannot walk drive or even stand because he/she has to take a crap so bad that they are paralyzed from the waist down
I was playing basketball when I was hit with the poopie paralyzer

I was drinking coffee and all of a sudden the poopie paralyzer kicked in

I was sleeping in the middle of the night when I woke up to the poopie paralyzer and had to crawl to the bathroom
Poopie Paralyzer by Nickylobes January 23, 2014
person 1: Where you been all night bro?
person 2: I been taking a phat ass poopie sorry.
Poopie by peepeepoopooman:) July 6, 2020