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Pronounced "Pee Yew" and also spelled "P U" or spelled out "Pfew!", "Phew!," or "Pee-yew!" this aging American interjection, often accompanied with a pinched nose or similar disgusted gesture, indicates the existence of a foul or overpowering odor. Its use seems to have peaked in the mid-Twentieth Century as a semi-euphemism for olfactory revulsion, but is still occasionally used today.
Betty: Archie, what happened to you? P U! (Waves hand in front of face)

Archie (red-faced): I fell in a pickle barrel at the grocery store.

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Sweet Dee Reynolds (in TV show "It's Always Sunny in Philadelphia," ca. 2010): Moms stink! P.U.!!

(episode "Frank Reynolds' Little Beauties," September 29, 2011)
P.U. by al-in-chgo May 24, 2018
Related Words
Silver ITR wheels for sale.
950 shipped or 900 p/u.
p/u by Marcus Thomas December 30, 2006
Literally, "Picture unrelated" Said whenever a picture has nothing to do with the regarding topic. Mostly used in imageboards.
Today was my first day at work. Everything's getting better than before!

p/u
p/u by anonhacks November 2, 2010
Help Help PU alert alert
P.U. by Stina February 17, 2004
Player's University, a place that's hella tight
"Man, girls, look at those muscles on WC!"
"I knooooww, does he go to P.U. or what?"
P.U. by WC September 15, 2004
Sarah: you saw the cute guy from school?
Jessie: yeah, we are friends... want me to p.u.o?
Sarah: YESSS!
P.U.O by misslea.\ October 24, 2020