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Spanish slang that is closest in English to being grossed out, or when something gives you the chills, creeps you out, disgusts you, or when something gives you the heebie-jeebies".
It can be used as a description or as a sensation.
"That weirdo on the subway gave me osco";
"This nasty restaurant is making me osco";
"Being in the cemetery at 3am, is giving me osco".
Osco by shortncomical January 26, 2019
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"katy stop acting osco"
"that girl is a complete osco"
osco by aklsdjfkadsjgkj December 26, 2006
Related Words

Osco Syndrome 

Main Entry: osco·syndrome
Function: noun
1 : a condition characterized by brief attacks of feeling the sudden urge to poo, often occurring with visits to exciting places such as Osco Drug, or a highly anticipated concert.
Oh my God! I'm so excited, I want to buy everything in sight! That entire wall of cosmetics is totally giving me Osco Syndrome. Do they have a can here?
Osco Syndrome by SMung December 25, 2007
A town of 30 people who do whatever the fuck they want. I only recommend visiting if you’re a redneck who isn’t afraid to do reckless shit. Not sure how any of them are still alive at this point.
“Oh you’re from Osco Illinois, you must own about 25 guns and a few dirtbikes.”

jewel-osco 

Jewel-Osco is a shitty place to work.
jewel-osco by Dork1234 January 1, 2018

getting jewel-osco-ed 

Two homosexuals having anal sex in public & during the day in the parking lot of the local jewel-osco grocery store.
While in town for the Gay Pride Parade, Eric witnessed two men getting jewel-osco-ed and took video footage on his iPhone.

Cold One-oscopy 

The act of butt bonging an ice cold brewsky. Also known as butt chugging or butt bonging.
After Brent lost a bet to his boys he had to take a good ol’ cold one-oscopy.
Cold One-oscopy by Bro Terry May 31, 2019