A man who talks and talks and talks, regardless of who is listening (or not listening). The origins of the word are derived from the word "man" and "fran drescher" (the actress who played the talkative nanny on the hit show "The Nanny".
Tom: You get your work done today ??
Bob: Hell no....man-fran popped by and wouldn't leave. He just kept talking and talking.
by manfran August 27, 2008
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A man who is extremely liberal and very gay.
Woah, don't kiss me bro, I'm not a San Fran Man.
Guys, it's 2016, San Fran Men should be accepted for who they are.
by TheAllKnowingRamen May 18, 2016
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