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A man who talks and talks and talks, regardless of who is listening (or not listening). The origins of the word are derived from the word "man" and "fran drescher" (the actress who played the talkative nanny on the hit show "The Nanny".
Tom: You get your work done today ??
Bob: Hell no....man-fran popped by and wouldn't leave. He just kept talking and talking.
man-fran by manfran October 16, 2008
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San Fran Man 

A man who is extremely liberal and very gay.
Woah, don't kiss me bro, I'm not a San Fran Man.
Guys, it's 2016, San Fran Men should be accepted for who they are.

Man Frandisco 

A pejorative and homophobic name for San Fransisco, CA (comes from its status as a gay-friendly city).
Fucking fags mincing around Man Frandisco...hope they all get the gay plague and die.
Man Frandisco by IronicTrollFace January 26, 2017

spider-man franchise 

(Noun) kid who only has one story and keeps telling it over and over.
Every time I hang out with Todd he tells the same exact story about how his dad was roommates with John Smoltz.

Spider-Man franchise

St.Francis Man 

St.Francis College man is the most understanding, caring, honest and loyal of all the other men.

These Francis men are most loved by Providence François girl and most hated by "St. James gyal".
A FUCKING BAD ST.JAMES GYAL- you know I does horn a St.Francis Man

QRC man - Like you fucking dumb, you horn loyal men to getting horn by me now, like you're a fucking mistake child awa? Daddy should've use a good condom like what the fuck, is fucking horn you want well take a fucking horn

San Francisco man hole 

When a gay man gets a huge cock in his ass. As the top man pulls out his dick will leave a hole resembling that of a San Francisco man hole. cock asshole gay
"man i got fucked so hard by Jimmy's fat cock, he gave me a San Francisco man hole! I'm still recovering from Friday night."

Francis man 

The best kinda man a gyal cud ask for Dey doh horn and like only one gyal sure bout da😵 💫
U hear Velma gt with a Francis man. Mbn
Francis man by JeffTheCucumber November 23, 2021