A person who sucks at life. They are incapable of performing basic and simple daily tasks (with the exception of masturbation).
You have your left turn signal on and are clearly trying to merge into the left lane; instead of slowing down to allow you to change lanes, the Jackwacker behind you speeds up to block your access. This guy is a complete Jackwacker; he sucks at life.
A person who acts as if they masturbate to themselves perpetually being bigoted jackasses, so as to overcompensate for their undoubtedly small penises.
Jackwanker 1: "Hur, hur, hur, he's craaazzzeee! HUR HUR!!"
Autistic person they're pointing to, under breath: "Ugh, what an asshole."
Jackwanker 2: "Hur hur, I'm an asshole furr bein' a bigot?! Hur hur PSYCHO!"
All jackwankers: *the furious sounds of their masturbation, followed by them stinking up the place with the miniscule droplets of cum that eventually leak out the tip of their micropenises*
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.