Two teachers, Adrian and Nick are enefriends. They play pranks on each other and talk about the other behind their back to their students, but then play poker together and go to each other's Election Day party.
Like boyfriend or girlfriend, but for someone you're dating who's genderqueer, agender, or otherwise outside the gender binary. "Enby" is short for non-binary.
Dwight and Jim from the Office, despite being mortal enemies, also deeply care for each other as well and ultimately feel incomplete when the other is missing, and therefore are actually enefriends.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.