To be on
one to the extreme, due to the effects of drinking 4Loko specifically, or any
potent, high powered malt liquor beverage in
general (ie; St. Ides, Old English, etc...).
"Did you
see that foo in da
club las' nite? Was he on one or what?"
"On one? Shiiit... That nigga was more than on one, he was 4
Lok'd da fuk out!"