cuntslut-ho Share definition Flag A derogatory insult coined by IMSA student Ajay Reddy. This insult was inspired by the random strings of curses of Mark Xue, the little brother of IMSA student Munan Xue. DeSouza: Get outta here. Ajay: U fuckin' cuntslut-ho. cuntslut-ho by IMSA student April 7, 2004 Get the cuntslut-ho mug.