A condition found in many theaters today in which semi-decent movies (or better) end in total failure, regardless of how amazing, relevant, entertaining, or realistic the movie was up to that point. Seems to have originated with the fourth Indiana Jones movie.
Jen: "So what'd you think of Knowing?"
Mike: "Definitely suffered from Crystal Skull Syndrome."
Jen: "That bad, huh?"
Mike: "Spielberg couldn't have raped it better himself."
Verb. When you've been lead to believe something was awesome, but it turned out to be crap. I.e. The movie by Paramount Pictures "Indiana Jones and the Kingdom of the Crystal Skull."