Verb. When you've been lead to believe something was awesome, but it turned out to be crap. I.e. The movie by Paramount Pictures "Indiana Jones and the Kingdom of the Crystal Skull."
Friend 1: Did you prank your roommate?

Friend 2: Yeah, I totally "crystal skulled" him into eating an Oreo filled with toothpaste, instead of creme.
by Ryan "RyTheNewsGuy" Ernde August 30, 2014
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When somones head resembles that of a crystal skull which was once found in an Indiana Jones film.
Woah Danny watch where you're swinging that crystal skull head!
by dannyjegghead March 04, 2014
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A condition found in many theaters today in which semi-decent movies (or better) end in total failure, regardless of how amazing, relevant, entertaining, or realistic the movie was up to that point. Seems to have originated with the fourth Indiana Jones movie.
Jen: "So what'd you think of Knowing?"
Mike: "Definitely suffered from Crystal Skull Syndrome."
Jen: "That bad, huh?"
Mike: "Spielberg couldn't have raped it better himself."
by my only paradigm March 24, 2009
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Something (often either an action or event) that taints the value/worth of everything previous.

Drawn from the movie "Indiana Jones and the Kingdom of the Crystal Skull" and refers to the damage done by the movie to the rest of the movies.

May not completely destroy the legacy, but rather it taints the image of the past.
Dude, that girl you hooked up with last night just crystal skull fucked your social life.
by hoyahaxa33 February 24, 2011
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When a film is remade or a film franchise is rebooted that ruins the positive connotations you had towards the original films.
Tim Burton's Charlie and the Chocolate Factory really crystal-skull-fucked the Gene Wilder version.
by Michigander Slammer May 23, 2015
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