Big Smoke is a character from GTA: San Andreas. In the mission titled "Drive-Thru", the crew goes to Cluckin' Bell, a fast-food restaurant. The crew all orders a decently-sized meal, only for Big Smoke to order something consisting of over 7,000 calories.
Big Smoke: "I'll have two number nines, a number nine large, a number six with extra dip, a number seven, two number forty-fives, one with cheese, and a large soda."
big smoke's order
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.