Refers to something you were unprepared for that was significantly more difficult or stressful to deal with that you could have anticipated it to be
The side effects from radiation for prostate cancer ate my shorts.

Hey, dude, stop hassling me over the money I owe you. I lost all my cash when my wallet was lifted. Trying to pay bills this month ate my shorts.
by PrettyBoyJohnny November 29, 2017
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