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Wryyyy is a loud, screech produced by Dio Brando, a vampire and antagonist of the Joestars. Instances of this screech can be first heard in the popular 1998 videogame, "JoJo's Bizarre Adventure" for the PSX. Dio uses his stand, The World, to freeze time. After freezing time, Dio proceeds to hurl knives at his enemy. During his knife attack, Dio unleashes his utmost horrifying shriek.
Dio: "Za Warudo!"
Dio: *Throws Knives
Dio: "WRYYYY!"

Jotaro: "Christ, my ears... That 'wryyy' was the worst of his attack."
Wryyyy by D3rbs July 15, 2018
Related Words

WRYYYY!! 

WRYYYY it's a JoJo reference (Jojo's bizarre adventures), to be more specific, to the character Dio Brando, who is an actual vampire, and villain of the part 1 and 3 of the anime (or comic/manga).
-Yeah, yesterday that Dio guy or something just came out of the sky and he was like, ZA WARUDO. WRYYYY!! With a fucking steamroller ya know.
WRYYYY!! by Just a JoJofag January 19, 2017
A sound you make when you have been at the bottom of the ocean for over a century and you come back up and have a bunch of people you dont know come fight you and you get beaten by a dump of a hag and a stupid hat boy.
"I AM DIO WRYYY"
wryyy by KjIoRtSaTrEoNWRYYY April 25, 2019
A particular sound you make when you have been at the bottom of the ocean in a coffin with your brothers body, which has no head, for over a century and you come back up and have a bunch of people you don't know come fight you and you get beaten by a dump of a hag who is a 'relative to Jonathan' and a stupid hat boy.
WRYYY by KjIoRtSaTrEoNWRYYY November 11, 2019
A war cry for vampires in the anime "Jojo's Bizzare Adventure" it is mostly used in part 1 and 3
JOJO: HAMON!
DIO BRANDO: YOUR HAMON IS WEAK JOJO WRYYY
WRYYY by WeakHamon123 October 22, 2020
1. An exclamation of comical despair.

2. A response to an unfortunate turn of events.

3. A quizzical outburst.
"I'm sorry sir, we are all out of Sour Gummy Worms...so I'm going to have to kill you to keep you quiet."
"WHYYYY!!!!!!!????"

"Luke, I am your father."
"WHYYYY!!!!???"
Whyyyy by Frisky Little Monkey February 13, 2010