A disorder in which a person wears glasses, has a large chin, is usually skinny, and is mildly nerdy and autistic. Up Oyndrome is most common among the Caucasian population.
by GreenMow.com June 13, 2024
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"...It really sucks having your upsyndrome flair up at a gay bar..."
We always thought Susie was weird, then the truth reared its ugly little head -- out of her pants when she was diagnosed with up-syndrome!"
5:00 News Headline:
"Rare condition found in man with up-syndrome -- are two penises better than one?"
"...It really sucks having your upsyndrome flair up at a gay bar..."
We always thought Susie was weird, then the truth reared its ugly little head -- out of her pants when she was diagnosed with up-syndrome!"
5:00 News Headline:
"Rare condition found in man with up-syndrome -- are two penises better than one?"
by PetShelterPimp May 13, 2005
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Up Oyndrome • up dog • up • Up Towns • Up Syndrome • up yours • Up Top • up north • Up-side down • up the butt
having so much down syndrome that you dont even know what is going on. you must have a lot of downs to be able to get upsyndrome. this is a very rare but life threating disease. but by having upsyndrome you are automatically a playa.
guy 1: is that an upsyndrome over there!?
guy 2: duh. he is so dumb. but he is a boss at the same time.
guy 1: word.
guy 2: duh. he is so dumb. but he is a boss at the same time.
guy 1: word.
by wordmang222 December 15, 2010
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