When a person who usually dresses and looks very plain or frumpy gets all sexy in sexy clothes, hair or makeup but doesn't impress you because you remember what the person usually looks like.
After Mertyle changed her usual look of sweats and baggy t-shits, she looked like a sexy potato at the party with that big hair, fake eyelashes and low cut dress.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.