When one womans breast is larger than the other.
Yo mama got one big titty and one little titty, they call the bitch biggie smalls! - Biggie Smalls syndrome
by Chips and subs November 15, 2010
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A female consisting of a fat ass and no tits.
"Hey Ricky, dating that chick that has Biggy Smalls Syndrome will ultimately lead to your downfall."
by T.L. July 5, 2005
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When someone has lived for so long in a small town that they form a sense of entitlement to themselves and act as if there isn't a relevant world outside of their town.

Someone with small-town syndrome usually is majorly concerned with gossip and events only happening with people in their town and let their life revolve around such meaningless rumors. They act as if life is high school. Parents/Adults and children all engage in cliquey behavior.

People with small-town syndrome usually don't realise they act this way, and may be insulted if pointed out.

People with small-town syndrome may have lots of trouble adjusting to life in the real world (wherever they move to out of the comfort of their family/friends also from same town)
Jeff and Jenny are all about meeting at the local café, (the only one in our town, so it is THE place to hang out and gossip), but the problem with the café is that no one seems to be able to talk about any current events in the world, they all seem to have small-town syndrome.
by vampire weekdays March 31, 2015
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A condition suffered by males aged 16-24 caused by lack of testosterone due to small testes, or balls. Symptoms usually include a bossy, superior attitude, uncharacteristically high voices, gay tendencies, and an overwhelming need to show they're better than everyone else. Small Ball Syndrome, or SBS is only treated by hanging out with other SBS sufferers to feel better about their lack of manhood
"Man, that punk can act all bad on the phone, but his squeeky voice betrayed his small ball syndrome"

"Sometimes, I date guys with small ball syndrome because I feel better dating a weak minded man that I can control"
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Small town syndrome is when people's thoughts are limited by a mental box, the less knowledge of the outside world, the smaller the box. This often happens when people do not venture past their back door.
"how can he talk about that culture in that way, he has never even spent time with those people"

"He is suffering from small town syndrome, he does not know what is out there"
by sunflower1800 November 6, 2014
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Also known as SMS. The condition manifests itself in adults whose mouths do not grow in proportion to their face as they mature. These individuals have child sized orifices. They can usually be identified using words like "supes" and "totes" which are easier for them to pronounce. See also Taylor Lamontism.
Taylor Lamont's small mouth syndrome was apparent as he made judgy facial expressions at the HRC Gala.
by Justcallmejulio12 September 29, 2013
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