Short for superhumans or "super-abled" in the "The
Boys" comics & TV series; most of whom were created using a
substance known as
Compound-V.
Butcher : Supe-heroes, Supe-villains, Supe-terrorists, they are all the fockin same. Let'
s kill those motherfockin supe freaks!
Hughie : No they are not all the same. You don't know what you're talking about.
Butcher : Shut up,
cunt! (*Long Stares).
Boy, you have no idea, do ya?!