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Another form of "Rest In Peace", when someone dies, directed to the deceased. Frankly, it sounds stupid. If you didn't know someone died and someone just posted "Rest Up, Bro", you may think that Bro was dealing with some ailment, exhaustion or was working to hard.
"Lost my cat today. Rest Up, Mr. Mittens".
Rest Up by Niggazandflies November 27, 2019
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iss like.... rest up
rest up big boy
rest up by pAnda 8 October 30, 2018

Restupidiculame 

It's Retarded, Stupid, Ridiculous, And Lame All Combined Into One Word!
My idea was great; yours was just restupidiculame!
Restupidiculame by Dominique Nelson December 21, 2008

restupulous

(ree-stew-pew-lus)

meaning ridiculously stupid, fuckin retarded
That guy is flippin' restupulous.
restupulous by chewy dick November 15, 2007

Restupidumb 

An mix of retarded, stupid, and dumb, meaning all three.
Jimmy fails at life, he is so restupidumb
Restupidumb by Rapetasm March 19, 2009
You're restupid, dont ever say anything like that again.
restupid by BIG Neek November 5, 2006

restupidtard 

the act of being stupid and retarded, all at the same time. very easily done.
Randy is such a restupidtard, he thought he could ace his SAT's after drinking the whole night before.