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Pop a Midol and relax

A term used in response to a person that is overly hysterical and emotional, often about something very minor or pointless. It is meant to imply the person is emotionally unstable.

Midol is an analgesic typically used for menstrual cramping. While the medicines within can be used for other pains, Midol is typically marketed for such, so the fact that someone would imply one needs a Midol is that one is acting overly emotional like they are a hysterical woman in too much pain from cramps that they cannot think straight. Despite its gendered origins, it's often said to men, with the added implication that the man is completely unable to think rationally.
Bob: Did you hear what Trump did today? He called a female reporter a dumbass?

Jack: Bob, pop a Midol and relax.
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