This is a phrase commonly used throughout the UK to indicate to a friend, colleague or even a total stranger that they have seriously annoyed a number of other people by word, action or attitude and that they can expect repercussions.
"Malcolm's just changed a whole load of databases that took months to set up, system support are fuming, he's really pissed them off!"
In baseball, when a batter hits the baseball with power. This type of hit normally results in a home run, however, it need not be a home run. It could be just a powerful hit!
At the Giants game Friday night, Cody Ross absolutely pissed on that ball.