A baby born to one or more crimminals; to have a parent who was convicted of a crime; a baby born to a mother who gave birth while imprisoned; a baby born to a fugitive of the law.
Made popular by the song of the same name as most popularized by the band called REO Speedwagon in the 1980's era, take on the run means to run away, usually from a bad or uncomfortable situation.
It may also now refer to taking a food order to go, aka running with it.
He suspects that you're cheating, so like a coward instead of confronting the situation you leave town and take it on the run.
I don't have time to sit down and eat. I'll just take it on the run.
When you have to pee in a movie but don’t want to miss anything, and must do the following mental equation: will the amount I have to pee cause enough discomfort to diminish my attention capacity for the remainder of the movie to an extent which is greater than the amount of the movie I would miss by making a mad dash to the restroom.
I saw Satantango last night, wonderful film but by the 5th hour I had to start doing pee calculus.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).