The insinuation of negative or hostile intentions, condescension, or disrespect from men, where none was intended by that man.
Karen was constantly complaining about her managers' "mansplaining" her job to her, because her paradigm couldn't accept that she was literally obligated to follow company policy, and that it hadn't anything to do with her gender. Her presupposition of masculine hostility and disrespectfulness on their part was an example of profound misandrystanding, bolstered by cognitive dissonance and denial.
Someone who despises or hates males. They usually talk about patriarchy and male privilege. While not all feminists are this way, many who identify as such and lead the movement are. Women that hate men enough will delve into political lesbianism and men who hate men enough will continuously denounce all men. The majority of people who have written definitions for men, boys and male are definitely misandrists.
Michelle told everyone at the female empowerment luncheon that she despised all men, she's clearly a misandrist.