Same as bitch but is the epitome of the word. A contestible female who is self absorbed, materialistic, and often conniving.
Person 1: I won't even deal with (lisa), she'll screw you in a second, and won't think twice.
Person 2: Sounds pretty bad.
Person 1: Oh, yeah. She's the megabitch.
by 3Dradio May 18, 2006
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A female of super-sized, intolerable, and uncalled for bitchiness with an extra side of "Oh no she didn't..."
Talking amongst the chattering crowd...

Girl 1: I totally understand it now Krystyna, thanks!
Girl 2: No problem babe. Happy I cleared that up for y-
Megabitch: (Snaps to Girls) -Uh HELLO?! Excuse me? Do you have a question? Well do you? Oh well, shut your face because nobody cares.
Girl 1: Whoa! Somebody woke up on the wrong side of the bed this morning with a stick up their ass!
Girl 2: Yeah, that cunt is a total megabitch.
by LongWay2Go February 18, 2009
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A bitch so bitchy that can shift any room from happy to mad within seconds.

They can derail your whole day and make you sad/mad for the rest of the week due to one small interaction.
“Gosh Dan, my sister seeks to ruin my day every chance she gets.”

“Sounds like she’s a megabitch, far beyond the encapsulated vessel by which normal bitches reside, and instead has transcended into the bitch Aether.”

“...What?”
by Görm Rat-el June 22, 2020
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