Fat buff Share definition Flag When someone is buff but has an outer layer of fat over their muscles. They tend to be males who lift a lot of weights but still eat a lot of pizza. "Do you think Drake is hot?" "Yea, he has that fat buff look going on, which I like" Fat buff by dafne89 September 8, 2015 0 0 Get merch Get the Fat buff mug. Buy Now — $32.95 See more merch