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Down To Fuck Shit Up

i.e. crash a party or wreck a party (in a good way or destructive way)
John: Hey man, there's a sick triple kegger at my friend's place with 40 sorority chicks. You DTFSU?
James: HELL YEA! Lets get some tonight!
DTFSU by Roomie#3 December 9, 2009
Related Words
DTFAS stands for "Down To Fuck A Sausage" brought to us by the film Sausage Party
Hey bun, are you DTFAS?
DTFAS by Superpete August 29, 2016