Definitions by Roomie#3

DTFSU

Down To Fuck Shit Up

i.e. crash a party or wreck a party (in a good way or destructive way)

John: Hey man, there's a sick triple kegger at my friend's place with 40 sorority chicks. You DTFSU?
James: HELL YEA! Lets get some tonight!

DTFSU by Roomie#3 December 9, 2009