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big issue 

Bless you! Muttered by a homeless person when they sneeze whilst you walk by them.
"Big issue!"

"Aww, bless you! But you're not having a hanky or my hard earned pennies"
big issue by Cardboard Carl June 16, 2003

The Big Issue 

A magazine homeless people sell to earn money.
I have no home so I sell the Big Issue on weekdays to afford food.
The Big Issue by BigIssueGuy March 7, 2009

big dick issues 

DICK OVER 14 INCHES IN LENGTH THAT CANNOT BE INSERTED INTO WOMEN OR IT WILL LEAVE SCARS
"I just can't handle my man during sex cause he has big dick issues"