B.U.F.F 

Big Ugly Fat Fuck, aka, that annoying guy who considers himself to be all that, but in reality said person is just a douche bag. The term is typically used in veiled sarcasm by everyone else around said person, since he is far too oblivious to the intended meaning.

Troy: "Hey Jerry, you're looking pretty B.U.F.F. there, you been working out?"

Jerry: "What? Nah, I'm just naturally this way."

Steve: (to Troy, after Jerry walks away) "Did you really mean that?"

Troy: "Yep, he really is a Big Ugly Fat Fuck"

B.U.F.F by Erkadurka December 1, 2011

B.U.F.F 

Sorta like the term D.U.F.F, meaning designated ugly fat friend, the word B.U.F.F means, black ugly fat friend.

Girl 1: Hey do you want to hang out later?
Girl 2: Yeah! Make sure you call Lisa, shes our B.U.F.F.
Girl 1: Oh, good call, I will see you girls later.

B.U.F.F by Steet August 21, 2009

b.u.f.f. 

Big ugly fat friend. Usually refers to a freind that makes you look a whole lot better in social situations.

I,m gonna go to the bar this weekend and bring my B.U.F.F. Jeff.

b.u.f.f. by Denny D. Bat April 28, 2006

B.U.F.F. 

big ugly fat friend. Every group of friends usually has one.

"Why does Sally hang out with them?"
"I don't know man, she's such a B.U.F.F.

B.U.F.F. by bma1 October 21, 2007

B.U.F.F. 

Better Understanding of Food and Fitness

This dude has a b.u.f.f.

B.U.F.F. by Björn the "NAZI" February 2, 2021

B.U.F.F.E 

Best unicorn friend for ever

Sophie is my B.U.F.F.E.

B.U.F.F.E by Dhrhrveg December 5, 2016

B.U.F.F.Y. 

An acronym that stands for Beautifully United Friends Forever... YES!

JB and Paul are each other's B.U.F.F.Y.

B.U.F.F.Y. by B.u.f.f.y. January 11, 2009