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Passing out or becoming totally oblivious of one's surroundings while standing upright, despite complete exhaustion.
After defeating the Minotaur in single combat, Bel stood in the rain of ashes from his explosive fire spell with a vacant gaze in to the black, unresponsive to the words of his friends, motionless like a statue, and completely mind-zero.
mind-zero by ClickityHack February 2, 2019
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Post Horizon Zero Dawn depression 

The feeling that hits, and eventually engulfs one, after they finish the game: Horizon Zero Dawn.

This mainly is due to the fact that the world of Horizon Zero Dawn is so immersive that a person loses themselve in it.

Finishing the game, and not knowing how long one has to wait for a potential sequel, makes them not want to play anymore.

It is not helped by the fact that no other world, coupled with its beautifully detailed ambience will ever come close to providing the perfect experience.

This leads to a type of depression, which eventually leads to a person putting his gaming career on an indefinite hold, until the sequel is released.
Post Horizon Zero Dawn depression

Aaron: Meridian doesn't exist in real life..

*gunshot*

Ace Combat Zero 

Ace Combat Zero is a prequal to Ace Combat 5. It centers around a mercenary group from Ustio, Galm Team. Galm Team consits of the main protaganist, Ciper (literally Zero in Japanese) and his wingman Solo Wing Pixy (Pixy for short). Ciper and Pixy are hired on as Ustio mercenaries and are a key asset in driving back the Belkans who invaded their nieghbors. Ciper and his wingman must take on Belkan Aces in all shapes and sizes. The game is narrorated from third-person by some journalist who also interviews the aces you fight with. There are many ways to end the game, and unlike Ace Combat 5, you can pick your special weapon. The game ends with you succesfully stopping the terrorist organization 'A World With No Boundries".
Me: Ace Combat Zero is awesome...but way too short.
Ace Combat Zero by iseeum May 22, 2008

Rem from Re: Zero 

who?

like im not kidding who is this Rem?
weeb: you know rem from Re: Zero?
human: no who is that?
weeb: *having a panic attack*
Rem from Re: Zero by Yunko December 10, 2020
Person: What does peak mean
Anyone with a brain: Oh that’s just Re:Zero
Re:Zero by unknown..aka September 28, 2021

Patient Zero 

Patient Zero is the first human infected by a new or recently discovered viral or bacterial outbreak. They usually have the most basic, least mutated form of the disease, which may either make them invaluable to medical efforts or completely useless. They can also often be used to determine where the disease came from.
Becky in Contagion was Patient Zero
Patient Zero by Snowskeeper April 3, 2013

Inbox Zero 

When you have no messages in your email inbox. Such a goal is often elusive, because the more email you clear out and reply to, the more new messages come in.
I reached my goal of inbox zero by Friday afternoon, but Monday morning I had 42 new messages.
Inbox Zero by herzogbr June 19, 2009