He/she thought that he/she was gonna fuck him up and make him go crazy, not knowing that the guy was fucked up long before them, and would be fucked up after they were gone, if it didn't kill him.
really drunk, high or in any state where you cannot calculate 2 + 2.
Synonyms include: druck, high, flicked, toasted, zonked, fried, baked, seitzed, tore up, zooted