Syke is said (or yelled) as sign of opposition to what was last said by
the one who says (or yells) it. Basically, if I say I have a nice girl, followed by a syke, it means my
chick is a
whore. :-) You can also say "not", "nae" or "or...".
Ryan : Your
bae gave me a call, she wanted to see me.
Marley : For what?
Ryan : She was flirting with me.
Marley is really surprised!
Ryan : Syke!
Marley slaps Ryan and walks away.