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Syke is said (or yelled) as sign of opposition to what was last said by the one who says (or yells) it. Basically, if I say I have a nice girl, followed by a syke, it means my chick is a whore. :-) You can also say "not", "nae" or "or...".
Ryan : Your bae gave me a call, she wanted to see me.
Marley : For what?
Ryan : She was flirting with me.
Marley is really surprised!
Ryan : Syke!
Marley slaps Ryan and walks away.
syke! by LebbEx February 20, 2019
Related Words
Basicly street slang for pretending, used in place of "playin" or "jokin"
yo momma just fell down the stoop... SYKE !
syke by Syke June 30, 2003
A word used to establish that the previous statement was false, usually followed by laughing. This is usually used when the user is unsure weather or not the joke was realised or wants to make it apparent that he or she was using sarcasm.
Dude that's some cool car you have...syke! XD Bahahahaha
syke by Meister_X April 28, 2010
An 80's urban slang meaning to take back or discredit/erase everything previously said in the last sentence.

(also sometimes spelled 'sike')
"I like you yer a cool guy...... SYKE!"
Syke by Kris parker December 28, 2005
Besides it's actual meaning, there was an oldschool rapper named Syke. He was one of Tupac Shakur's greatest friends and appeared in serveral of his songs. He's most famous for singing in 2Pac's songs "Picture Me Rollin'" and "How Long Will They Mourn Me?"
So day after day, ride after ride, we'll all hook up on the other side. Watch over your family and your newborn. Till we meet again homie.

-Syke, in his tribute to Kato
Syke by Wes Schaller December 21, 2006
A misspelling of the term "Psych". Most often used by people who have no idea what the term actually means, and only a loose grasp of what the appropriate context is to use the term. Also misspelled "Sike"
Brody: "Your mom blew me last night!! Syke!!"
James: "I'd have to believe it before you could actually Psych me out. I bet you'd spell it with an S too, wouldn't you?"
Brody: "Whatever, faggot. You SO believed it!!"
James: "Stop breathing my air."
Syke by AutomaticJack August 30, 2015