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This word combination refers to the state of a person when on drugs.
tripper- "Oh, I'm on a sick one!"
sick one by beautiful biotch February 15, 2010
Something very cool which you are pleased about.
"Hey man I bought you some weed" "Sick one"
sick one by Melissa180 May 26, 2006
When your friends say something that is not true or extremely retarded or do something that is extremely retarded
Person: "You have as many brain cells as a fucking ant"
You: "sick one mate"
Sick one by Big Mr Tryhard April 14, 2021

On a sick one 

Someone Extremely high, on their own personal mission, totally blowing it; obviously high having lots of fun without a care.
Billy is showed up with his truck entirely repainted, he must be on a sick one
On a sick one by Sickfn December 3, 2016

a sick one 

If you get a party favor after 2am it is considered a sick one.
"What did you do last night?"
"I went on a sick one..."
a sick one by Aria Darling January 11, 2023

Off a sick one

Can be used in either a positive or negative context:

Depending on the temperament of the individual using it.

- Most commonly related to the phrase “on a sick one”

- “ off a sick one” means the person/object/or situation you are referring to is extra-ordinary. Or not the normal. Out of the baseline.
“Yo my uncle beat me, he is off a sick one today”

“My roommate bought a 30 rack he is off a sick one.”
Off a sick one by 10E03 October 21, 2025