A metaphor describing someone who complains a lot or who is given to whining.
Andy: "But guys!...I don't want to go to Bennigans, their food gives me the runs!"
Carl: "Quit acting like a little bitch with sand in the vagina!"
Tina: "Yeah, here's a douche!"
Someone or something that bites your ankles.
To a postman, an ankle biter is often known as a dog.
To an adult, an ankle biter may be a toddler.
To hikers, an ankle biter is sometimes a tick.
And so on.