ANGEL: U AINT GONNA DO SHIT
SALLY:"Wuss good then, run me the ones right now"
ANGEL: Aight bitch wuddup?!
Joe: yo! they bout to run the ones!
SALLY:"Wuss good then, run me the ones right now"
ANGEL: Aight bitch wuddup?!
Joe: yo! they bout to run the ones!
by NYDREE October 05, 2006

It means the same thing as when you tell someone to fight you, mix you, throw hands, or any other term
by Bigblackducl August 03, 2017

*Sees three people sitting next to a basketball court*
"Aye, y'all tryna run one?"
ALTERNATIVELY
Friend: *Stares at your copy of Super Smash Bros sitting on the table*
You: "You tryna run one?"
Friend: "Run them hoes then!"
"Aye, y'all tryna run one?"
ALTERNATIVELY
Friend: *Stares at your copy of Super Smash Bros sitting on the table*
You: "You tryna run one?"
Friend: "Run them hoes then!"
by Yodaddybitch August 11, 2017

to spank it, masterbate.
by kevin barnard August 12, 2003

To masturbate, usually referring to guys only. The term is used when a guy has the urge to whack it after seeing a hot girl.
I was dancing with this hot chick at the club, but I didn't go home with her. When I got home, I was so horny that I had to run one off.
by RexGibson March 06, 2004

by Lovebug02 May 28, 2018
