Presinoia describes a Delusional Disorder, a mental health condition where any political aspirant who suddenly and genuinely believes he/she has a chance of getting elected POTUS (President of the United States); when in fact, those chances are the exact same as he/she becoming the next Pope, or Czar of Russia, or the Grand Vizier of BoogaBoogistan.
Think of any marginal or fringe candidate of any political party who "announces a committee" to explore the possibility of running for POTUS.
In 2011, there are dozens of such people, mostly Republicans, but other political parties as well, who are political aspirants for the 2012 POTUS election cycle.
Sam Smith announced he is running for President. He must be suffering with presinoia. His chances of getting elected are zero.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.