Guy: hey u wanna a nickel girl: ok... guy : uhh what are y- HEY so umm why did u just tickle my pickle cuz u gave me a nickel so nickel to tickle a pickle duh
When you are completely roasted toasted and caught by surprise. A term you should not often use as you should always have an ace in your hole. Hopefully, when you do use this term, those around you will be so completely and utterly destroyed both physically, mentally, and spiritually that they'll bow down and worship you.
Teacher: "Did you say further? Further means more and you can't be even more of more; the proper term is 'farther!'"
You, me, or any enlightened child: "Well slap my ass and tickle my pickle, I'm going to kill myself!"
Thicc Boi: "WHO GOES NEXT? If he's on my left and he's on my right, WHOSE IN THE MIDDLE??
Enlightened one: "Well slap my ass and tickle my pickle he's got more chromosomes than me!"
Highly malignant tumors rely heavily on anaerobic glycolysis (metabolism of glucose to lactic acideven under ample tissue oxygen; Warburg Effect) and thus need to efflux lactic acid via MCTs to the tumor micro-environment to maintain a robust glycolytic flux and to prevent the tumor from being "pickled to death".
It is said of the situation where a person has the bad luck to make contact with his testicles against an undefined surface or object, intentioned or not.
Given the nature of the word, it is more appropriate to design cases where the interaction is made with a moving object, for example, a ball.
Although it is extremely painful for the victim, it tends to be considerably funny to people who witness it.
Today in the baseball game the pitcher took a nutshot; the baseball hit him in the nuts.
Man, I just watched the funniest nutshot video ever.