In football, intercepting a pass and running it back for a touchdown.
Dude 1: Man, I missed the end of the Bears game what happened?

Dude 2: ARE YOU SERIOUS? Tillman pick-housed Garcia in overtime for the W.
by Eleven58 November 19, 2007
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A popular line from Grand Theft Auto: San Andreas said by Big Smoke, during the intro mission of the game. It's the first thing Big Smoke says, too.
Big Smoke: *storms in with a baseball bat* You picked the wrong house, fool!
CJ: 'ey, 'ey 'ey 'ey, Big Smoke, it's me, Carl, chill, chill!
by Gamma the Enigma August 20, 2016
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"You picked the wrong house, fool!" are the words spoken by Big Smoke as he proceeds to advance on CJ with a baseball bat. When he says this it makes virtually no sense so here's a good dumber-down for you:
YOU PICKED THE WRONG HOUSE FOOL YOU CHOSE THE WRONG PROPERTY SIMPLETON YOU HAVE CHOSEN TO BURGLE THE INCORRECT ESTATE NINCONPOOP INEGLECT TO INFORM TO YOU THAT YOU APPEAR TO HAVE CHOSEN THE OPTION TO THE INCORRECT AREA OF PRIVATE PROPERTY AS IAM PRESENT AND READY TO STRIKE YOU WITH A LARGE WOODEN POLE USED IN THE VERY COMMON AMERICAN SPORT KNOW AS BASEBALL TO THE AFRICAN AMERICAN MALE WHO HAS APPEARED TO HAVE ENTERED THE HOUSEHOLD IN WHICH I AM CURRENTLY PRESENT I APPEAR TO HAVE TO TELL YOU THAT YOU HAVE CHOSEN TO TRESSPASS INTO A VERY POOR CHOICE OF AVAILABLE HOUSES AS I AM HERE WITH A HEAVG BLUNT OBJECT AND COULD IFICHOOSE STRIKE YOU MULTIPLE TIMES UPON THE HEAD AND FACE WHICH WOULD UNDOUBTABLY CAUSE SERVERE AND POSSIBLY LETHAL INTERNAL BLEEDING WITH THIS INFORMATION BEING PRESENT I STRONGLY RECOMMEND THAT YOU LEAVE THIS HOME BEFORE THE SITUATION MUST BE ESCALATED ANY FURTHER
Big Smoke: "You picked the wrong house, fool!"
CJ: "Woah, Woah, Big Smoke its me, it's CJ!"
by Dmitri Strelnikov January 20, 2017
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The thing you say when a burglar breaks inside your house
Burglar: Breaks in
You: You picked the wrong house, Fool!
by PetrosNoob101 December 12, 2019
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