Nuzlocke

The thing that happens when you kill the Wall of Flesh in various Pokémon games.

It's a Terraria joke. Laugh.
Because iterations of Nuzlocke challenges are literally hardmode.

Nuzlocke by Exodim November 30, 2021

nuzlocke

ht tp://bulbapedia.bulbagarden.net/wiki/Nuzlocke_Challenge

(Usually recorded into a comic or piece of literature and characters are given personalities. ie. gary the jerk eventually becomes the protagonist's best friend or boyfriend......or murder victim)

(copy and paste, get rid of the space)

Random guy/girl: "Hey, you coming over tonight?"

Friend: "Nah, I gotta finish the 17th page of my Nuzlocke, my eevee died, it was sad"

nuzlocke by Renara October 9, 2013

Nuzlocke Challenge 

An optional and more difficult way to play a pokemon game.
1. Catch the first Pokemon you encounter in each route/cave/whatever and nothing else. If you fail to catch it, too bad, continue onwards.
2. If your Pokemon faints, consider it dead and release it.
Additional/Optional rules include:
3. No use of healing items. You may only heal at pokemon centers.
4. If a pokemon that knows an HM move faints you may not use the HM. If no other pokemon you have can learn the HM you automatically lose and must start the game over.
5. Make a comic about anything significant that happens. You may be creative and turn it into a more original story.
6. Nickname everything you catch.
Grinding is allowed and any additional Pokemon that don't fit in the party may be stored in boxes. If all your Pokemon faint it's game over.

He tried the Nuzlocke challenge and had to release his starter after it was knocked out at the first gym.

Nuzlocke Challenge by Fish lemonade August 20, 2010

NumLocker 

averse to studying mathematics

Most people are NumLockers

NumLocker by nebiru100 January 26, 2012

Nutzlocked 

Being Nuzlocked is being stuck in a relationship you don't want to be part of.

Calling someone Nutzlocked is like calling them out for being trapped.

you can use it to describe someone's situation, can be used when you regret your choice and get together with someone.

old daves misses won't let him do that, he's nutzlocked.
old dave is totally Nutzlocked, he's not getting out of that for a while.

I'm Nutzlocked mate I'm looking for a way out

Nutzlocked by SoakSmith September 29, 2021

Isaac nuzzlocke

Isaac nuzzlocke is created by b1dp

Rules (that i found on cneto's stream)

Isaac nuzzlocke rules
-start with new save file
-if character dies you cant use this character
-if you Die at daily you cant Play dailies again
-if you Die in rebirth challenge you cant do rebirth Challenges but you still can do other Challenges
-every secret counts for 1point, challenge 5 pointa, hard mode Mark 10points
-clicker is illegal
-console is illegal
-resseting isn't allowed
-tainted cain crafting edens blessing is banned

Isaac nuzzlocke by Acdbdcez September 14, 2021