Ninnypuss Share definition Flag A ninnypuss is a person that frequently annoys, angers, or upsets others. My brother is a ninnypuss because he tries to act like he is the perfect child all the time, and he gets all the attention. Ninnypuss by prettycoolperson June 3, 2010 0 0 Get merch Get the Ninnypuss mug. Buy Now — $32.95 See more merch